We previously reported that TGFBIp is a lymphangiogenic factor that induces metastasis via three probable mechanisms: (1) by increasing lymphatic density and consequently augmenting surface contact with cancer cells; (2) by increasing CCL21 expression in LECs and promoting the migration of cancer cells; and (3) by increasing lymphatic permeability and facilitating the intravasation and/or extravasation of tumor cells8 (Supplementary Fig. S8 online). This evidence concerns the gene CCL21 and cancer.