In fact, recently the Evaluation of Genomic Applications in Practice and Prevention Working Group (EWG) has found insufficient evidence to recommend PCA3 testing not only for deciding to conduct initial biopsies for PCa at risk men (e.g. previously elevated PSA test or suspicious digital rectal examination) but also for deciding when to rebiopsy previously biopsy-negative patients for PCa. Here, KLK3 is linked to posterior cortical atrophy.