Considering the identification of the key regulator role of TUG1 on CRC cell metastasis invitro, we next established an invivo experimental liver metastasis model by injecting human SW480 CRC cells into the spleens of BALB/c nude mice and followed their ability to invade-via the portal vein-the liver to form metastases and then investigated whether TUG1 plays an important role in the liver metastasis of CRC. Here, TUG1 is linked to colorectal carcinoma.