EFEMP1 and osteoporosis: Among these: (1) EFEMP1, although not well annotated, has been shown in in situ analyses to be expressed in the condensing mesenchyme, which gives rise to bone and cartilage, and in developing bone structures of the cranial and axial skeleton during murine embryogenesis [63]; (2) SPTBN1, which is involved in healing properties of human bones [64] and is associated with human osteoporosis [65, 66]; and (3) FSHR, which influences bone remodeling and osteoclast proliferation activity in postmenopausal women [67].