The reduction in GILZ was associated with the hallmark featureof SS (i.e., leukocyte infiltration of salivary tissues) as well as marked reductionin Del-1 but marked increase in IL-17 expression (i.e., Del-1/IL-17 imbalance).Collectively, these observations implicate a pathogenic role for GILZ in salivarygland abnormalities of SS and associated Del-1/IL-17 imbalance. This evidence concerns the gene TSC22D3 and synovial sarcoma.