Analyses of the 5mC profile using a genome visualization tool detected the expected DNA hypermethylation at an estimated 3.8-kb-long region surrounding the transcriptional start site of FMR1 in FXS PBMC (region II covering −3.5 kb/+0.3 kb of the FMR1 start site, ChrX: 146,990,000–146,993,800) (Fig. 1c, Table 1). The gene discussed is FMR1; the disease is fragile X syndrome.