RHO and type 1 diabetes mellitus: As indicated by Fig. 8a–c, the genes in SNP-CNV double hotspot windows with top-5% levels of SNPdb, SNP1K as well as CNVG occurrences are enriched in gene-groups related to immune response, alpha-defensin, sensory perception including olfactory and rhodopsin-like systems, Type I diabetes mellitus, cognition and G-protein coupled receptor protein signaling pathway.