Chronic inflammation is essential for tumor development, a thesis that is backed by various observations: tumors often arise from sites of chronic inflammation, immune cells can be found in almost all types of cancer, experimental blocking of inflammatory mediators (e.g., HMGB1) inhibits cancer development and administration of anti-inflammatory drugs (AID) was even reported to reduce the risk for certain tumor entities reviewed in [142]. This evidence concerns the gene HMGB1 and neoplasm.