HMGB1 and neoplasm: Interestingly, HMGB1 release into extracellular space seems to be dependent on the type of chemotherapy applied, as tumor cells of various entities treated with alkylating agents melphalane or paclitaxel released HMGB1 measurably after 36 to 40 h, whereas treatment with oxaliplatin led to no significant extracellular elevation [205].