Sixty percent of NECs in the Basturk et al. study [128] had a Ki-67 index >60%, similar to a Japanese study with 61% of PNECs having a Ki-67 >55% [92], whereas in the Nordic NEC study [4] non-poorly differentiated tumours were not excluded, and only 30% of cases had a Ki-67-index >55%. The gene discussed is MKI67; the disease is neoplasm.