CRP and osteoarthritis: Looking at potential blood biomarkers for painful osteoarthritis, namely three collagen markers and two inflammation markers (high-sensitivity C-reactive protein and matrix metalloproteinase-mediated breakdown of C-reactive protein), Arendt-Nilsen et al. [24], in a methodologically interesting study, recently reported the associations between these five biochemical markers and experimental markers of pain (pressure–pain thresholds, temporal summation, and conditioned pain modulation).