Several studies had found that the possible reasons for the adaptability response may as follows: In the process of tumor growth, when the blood supply could not meet the needs of the tumor growth, HIF-1α would be activated by the hypoxia within the tumor, a series of HIF-1α dependent genes activated, regulating the biological characteristics of tumor from multiple pathways, so that the adaptive changes happened10, 11. This evidence concerns the gene HIF1A and neoplasm.