The results of this study demonstrated that HIF-1α may play crucial roles in some important processes of tumors, for example the growth progress and metastasis of the squamous cell carcinomas, or tumor angiogenesis, the plasma level of HIF-1α has crucial significance for the prediction of the prognosis of patients with NSCLC, especially in squamous cell carcinomas. The gene discussed is HIF1A; the disease is squamous cell carcinoma.