NFKB1 and type 2 diabetes mellitus: The beneficial role of polyphenols in T2DM is receiving attention, and these benefits include: protection of pancreatic beta-cells against glucose toxicity, anti-inflammatory (modulation of NF-Kb, activation of TNF-alpha, IL-6 and VEGF) plus antioxidant effects, decreased starch digestion, inhibition of advanced glycation end product formation, and beneficial effects on gut microflora [16].