The nuclear factor (NF)-κB transcription factor family are important regulators of immune and inflammatory responses.1 Furthermore, aberrantly active NF-κB is associated with many human diseases, including cancer.2, 3, 4 While the pathways leading to nuclear translocation of NF-κB provide a primary level of regulation of its activity, NF-κB subunits are also subject to a wide range of post-translational modifications (PTMs). Here, NFKB1 is linked to cancer.