Our data do however support a role for autophagy in the optimal growth of bladder cancer cells, which may underlie the trend for autophagy siRNAs or ATG7 KO to mildly protect against FGFRi and mTORi.44, 45 Furthermore, by robustly blocking autophagosome degradation and recycling with CQ and BafA1, we also rule out a role for constitutive bulk autophagic flux as a cytoprotective pathway under AKTi and mTORi in bladder cancers. The gene discussed is ATG7; the disease is urinary bladder carcinoma.