Based on previous evidence demonstrating the role of UNC5C and other Netrin-1 receptors, such as DCC, as tumor suppressors and their association with intestinal tumor initiation and progression17, 18, 19, 20, 21, 22, 23, 24, Coissieux et al. hypothesized that germline mutations in the UNC5C gene might predispose to CRC25. This evidence concerns the gene UNC5C and intestinal neoplasm.