More recently, Küry et al. 26 sequenced exon 11 of UNC5C, which contains p.A628K, in 120 familial CRC cases of unknown genetic etiology, either with mismatch repair (MMR)-deficient or proficient tumors, 35 polyposis patients, 23 patients affected with Lynch syndrome-spectrum tumors, 132 carriers of germline mutations or variants of uncertain significance (VUS) in the MMR genes, and 300 unaffected controls. This evidence concerns the gene UNC5C and colorectal carcinoma.