Under further analysis, we found that the apoptosis of podocytes and tubular epithelial cells was prevented, the overexpression of caspase-3 was suppressed, and the proliferation of glomerular endothelial cells was increased, which indicated that inhibiting podocyte apoptosis or promoting vascular regeneration may be one means of preventing kidney complications arising from diabetes. Here, CASP3 is linked to diabetes mellitus.