IL5 and Increased total eosinophil count: Subjects in cluster E (steroid-resistant TH2-mediated, eosinophilic) have high serum periostin levels, sputum eosinophilia, sputum IL-5 levels, and fraction of exhaled nitric oxide (Feno) levels despite high-dose ICSs (1600-2000 μg of beclomethasone dipropionate) or oral corticosteroids (40% to 46% of participants).