CXCR4 and neoplasm: CXCR4 expression was stronger in the xenograft tumor containing CAFs compared to tumors without fibroblasts or containing NFs (Fig. 2f) and increased gradually in endometrial tissues as they progressed from NE to HE to AHE and finally to EC tissues (χ2 = 139.485, P = 0.000; Fig. 4d).