These included UMODpXR, a soluble variant of the polymerization region of human uromodulin (UMOD)/Tamm–Horsfall protein, a urinary molecule involved in kidney protection and hypertension (Rampoldi et al., 2011, Trudu et al., 2013); the zona pellucida (ZP)-C domain of UMOD; a fragment of vitelline envelope receptor for lysin (VERL-Fa) (Swanson and Vacquier, 1997); and the N- or C-terminal region of human endoglin/CD105 (ENG-N and ENG-C), a type I transmembrane glycoprotein involved in angiogenesis (Gougos and Letarte, 1990). The gene discussed is UMOD; the disease is Hypertension.