In addition to degrading the collagen surrounding new vascular cells [23], MMP14 releases latent TGF-β1 from latent TGF-binding protein (LTBP) and activates other MMPs secreted to the medium, such as MMP2, which has a critical role downstream of MMP14 for angiogenesis-mediated tumor invasion [24]. The gene discussed is MMP14; the disease is neoplasm.