We have not assessed whether direct rottlerin effects on mTORC1 and/or p62 modulate metabolic reprograming in PaSC, but our data associate inactivation of mTORC1 and p62 accumulation with reduced fibrogenic potential and differential transcriptional regulation of inflammatory cytokines, results that have important implications due to the pleiotropic effects of PaSC in the tumor stroma. The gene discussed is SQSTM1; the disease is neoplasm.