On the other hand, age, diabetes duration, hospitalizations, CVRR, coronary heart disease, and unemployment were considered indicators of aging. The factor sex differences included the variables sex, calorie intake, and cooking, while insulin secretion contained the variables CPI, F-CPR, retinopathy, diabetes duration, ΔCPR, U-CPR, sulfonylurea, and insulin treatment. The gene discussed is INS; the disease is diabetes mellitus.