In psoriasis, T-cells (both CD4+ and CD8+) are known to cause low production of Th2 cytokines (IFNγ, TNFα, and IL-2) and high production of Th1 cytokines (IL-4, IL-6 and IL-10), leading to polarization of the type 1 pathway [34]. The gene discussed is IL10; the disease is psoriasis.