Indeed, the expression of two HSC70 isoforms were upregulated by pathogen infection, while loss-of-function mutants of individual cytosolic HSC70 genes do not display defense phenotypes [49] LTP genes (comp25940_c0) and PDR-type ABC transporter gene (comp20414_c0) participating in MAPK cascade to negatively regulate the defense response function downstream of this pathway. Here, HSPA8 is linked to infection.