In the present study, we demonstrate, through the analysis of multiple MM cell lines and primary myeloma cells from MM patients that myeloma cells do express a number of EMT markers (e.g., E-cadherin, Vimentin, Fibronectin, and RANK) and that the expression of these markers is regulated by HSPE. The gene discussed is TNFRSF11A; the disease is plasma cell myeloma.