VIM and neoplasm: To determine whether HPSE promoted angiogenesis through the induction of a mesenchymal phenotype in the host vascular endothelial cells in the tumor microenvironment, HUVECs were cultured in conditioned medium (CM) of HPSE-low or HPSE-high cells and the expression of the mesenchymal marker vimentin was analyzed by Western blot.