As to TGFβ receptor signaling, it has been shown that c-SRC can phosphorylate TGFβ type II receptor directly at Tyr284 and this controls the TGFβ-driven activation of p38 MAPK and induction of EMT, which in turn lead to a promotion of proliferation and invasion in breast cancer cells [43]. The gene discussed is TGFB1; the disease is breast cancer.