Therefore, we can not exclude the possibility that the impairment of SRC activity can contribute directly, or has a synergistic effect with the decrease of CD44 co-receptor level, to dampen the EGF-induced or TGFβ1-induced mesenchymal marker expression in the NMU-knockdown endometrial cancer cells (Figure 8). The gene discussed is TGFB1; the disease is endometrial cancer.