Applying this approach to myelin proteins of known interest in MS research in the first instance reviewed in [55], we identified potential cross-reactive responses involving a number of major myelin antigens (Table 3) including experimentally confirmed HLA-DRB1*15-restricted epitopes associated with encephalitogenic T cell responses (asterisked) including 2',3'-cyclic-nucleotide 3'-phosphodiesterase, alpha B crystallin, myelin basic protein and oligodendrocyte-specific protein. The gene discussed is CRYAB; the disease is myeloid sarcoma.