The regulatory regions of hematopoietic genes are known to be bound by RUNX1, as discussed, as well as a transcription factor complex composed of stem cell leukemia protein (SCL)/T cell acute lymphocytic leukemia protein-1 (TAL-1), LIM domain only 2 (LMO2), GATA1, and GATA2 ([1, 140, 146–148], all of which have been implicated in EHT. The gene discussed is TAL1; the disease is essential hypertension, genetic.