Mutations involving the cohesin complex can be seen in myeloid neoplasms, with individual mutational frequencies of ~12% AML, ~8% MDS, ~6% chronic myeloid leukemia, ~1% MPN and ~10% in CMML.69 These mutations frequently coexist with other myeloid relevant mutations, including TET2, ASXL1 and EZH2. 69 The prognostic impact of these mutations remains to be determined. This evidence concerns the gene ASXL1 and myelodysplastic syndrome.