PDGFRB and chronic myelomonocytic leukemia: Chromosomal translocations involving PDGFRA/B have been associated with myeloid neoplasms characterized by prominent eosinophilia and responsiveness to imatinib.12, 13 At times, PDGFR-rearranged myeloid neoplasms can be associated with monocytosis and BM dysplasia, but given their unique responsiveness to imatinib, these are no longer classified as CMML.