RUNX1 and acute myeloid leukemia: It helps regulate the expression of G-CSF, interleukin-3, T-cell receptor and myeloperoxidase.73 Mutations and translocations involving RUNX1 have been well characterized in core-binding factor AML (t(8;21)(q22;q22) RUNX1/RUNX1T1) and MDS.73 In CMML, RUNX1 mutations are seen in ~15% of patients.7, 74, 75 These mutations do not impact OS but can be associated with a shorter LFS, especially in patients with C-terminal mutations.7, 74, 75