In CMML, EZH2 mutations are infrequent (~5%) and do not have an independent prognostic impact.7, 59 The UTX gene (ubiquitously transcribed X chromosome tetratricopeptide repeat—chromosome Xp11.2), encodes a lysine-specific demethylase (6A). This evidence concerns the gene KDM6A and chronic myelomonocytic leukemia.