These observations provide strong evidence to suggest a compensatory effect of miR-155 in the tumor and the tumor microenvironment, which may explain why we did not observe any significant difference in the tumor growth in Brca1cko/cko;Trp53cko/cko;K14 Cre mice in miR-155ko/+ and miR-155ko/ko backgrounds (Figure 1A). Here, KRT14 is linked to neoplasm.