OPN1SW and hepatocellular carcinoma: Heterogeneity was significant among the included studies [12, 20, 30, 31, 39, 47], which described A1762T/G1764A dual mutations from chronic HBV infection in HBV genotypes B and C. Chronic HBV-infected patients with genotype B had a significant lower incidence of A1762T/G1764A dual mutations compared with those with genotype C (OR = 0.30, 95% CI = 0.18-0.52, P < 0.0001, Figure 2.1); no heterogeneity was found when we compared BCP dual mutations between HBV genotypes B and C in HCC patients (P = 0.27, I2 = 24%).