Overexpression of Exo70 in human hepatoma PLC/PRF/5 cells corrected the dysregulated cell cycle caused by knocking down endogenous HNF4α (Figure 6A–6B); in contrast, overexpressing HNF4α showed no influence on the G2/M cell cycle arrest induced by knocking down endogenous Exo70 (Figure 6A–6B). The gene discussed is HNF4A; the disease is hepatocellular carcinoma.