The expression of HNF4α was significantly increased in HCC as compared to the adjacent non-tumor tissues, indicating a tumor promoting role of HNF4α in HCC [32]; however, another study reported that overexpression of HNF4α decreases the tumorigenicity of hepatoma cells [33], defining HNF4α as a hepatoma tumor suppressor. This evidence concerns the gene HNF4A and hepatocellular carcinoma.