These included BACH1, a transcription factor, which is upregulated in several cancers and known to be regulated by the let-7 family [34], HMGA1, which is involved in cell differentiation and apoptosis and upregulated in several cancers [35], SLC4A4, which is upregulated in chronic myeloid leukemia stem cells [36], ZBTB5, which function as an oncogene by repressing the cell cycle arrest gene p21 [37], and ACSL6, which has been shown to be part of a gene fusion in MDS and polycythemia vera [38, 39]. This evidence concerns the gene ZBTB5 and chronic myelogenous leukemia, BCR-ABL1 positive.