More thorough transcriptional profiling in A673 and TTC-466 Ewing sarcoma cells intriguingly showed LSD1 inhibition flips both sides of the transcriptional profile for both EWS-FLI and EWS-ERG, respectively, upregulating repressed targets and vice versa [22] (Figure 2). The gene discussed is KDM1A; the disease is Ewing sarcoma.