The findings reported herein indicate that EGCG inhibits chemokine secretion in orbital fibroblasts from patients with TAO, and in particular, the decrease in IL-8 secretion was statistically signifiant and the mechanisms responsible for this can be attributed to the suppression of the NF-κB, and MAPK pathways, including the p38, and ERK pathway. This evidence concerns the gene NFKB1 and thromboangiitis obliterans.