As described in Table 3, multivariate Cox proportional hazard model to predict BCR showed that preoperative serum PSA levels (HR = 1.011, 95% CI 1.00–1.016, p<0.001), biopsy Gleason scores (HR = 2.411, 95% CI 1.843–3.102, p<0.001), ratio of tumor extent in biopsy scores (HR = 2.512, 95% CI 1.521–4.025, p<0.001), total number of positive core (HR = 1.597, 95% CI 1.275–2.000, p < 0.001) and ratio of base positive cores (HR = 1.512, 95% CI 1.030–2.183, p = 0.001) were independent predictive factors of BCR after RP. Here, KLK3 is linked to neoplasm.