In a multivariate logistic regression analysis to identify the factors associated with SVI, preoperative serum PSA level (odds ratio (OR) = 1.011, 95% confidence intervals (CI) 1.005–1.016, p < 0.001), biopsy Gleason score (OR = 2.411, 95% CI 1.843–3.102, p<0.001), ratio of tumor extent in biopsy (OR = 2.512, 95% CI 1.521–4.025, p<0.001), total number of positive core (OR = 1.597, 95% CI 1.275–2.000, p < 0.001) and ratio of base positive cores (OR = 1.512, 95% CI 1.030–2.183, p = 0.001) were found to be independent predictive factors of SVI following RP (Table 2). Here, KLK3 is linked to neoplasm.