SNAI1 and squamous cell carcinoma: In the present studies of chemically-induced two-stage skin carcinogenesis, we demonstrate that Slug and Snail are induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), that Slug and Snail are persistently overexpressed in 7,12-dimethylbenz[α]anthracene (DMBA)/TPA-induced squamous cell carcinomas and that Slug modulates TPA-induced epidermal hyperplasia and cutaneous inflammation.