However, it was noted that HAM/TSP patients presented an independent association with the polymorphism in IL28B SNP rs8099917 (GG), when compared to asymptomatic HTLV-1 carriers [19]; such a finding has not been reported for other infections, such as HIV and HBV infections [20], except for patients with acute HIV infection, whose response to antiretrovirals was related to SNP rs12979860 [21]. The gene discussed is IFNL3; the disease is tropical spastic paraparesis.