TREX-1 (three prime repair exonuclease), which degrades cytosolic DNA, preventing unnecessary immune response against free nucleic acids, is a limiting factor for HIV-1 and polymorphism of a single nucleotide rs3135945 and was associated with susceptibility to HIV infection, emphasizing the participation of TREX-1 in anti-HIV response [65]. The gene discussed is TREX1; the disease is HIV infectious disease.