AGT and glomerulosclerosis: Finally, atorvastatin attenuated renal oxidative stress, exerted anti-inflammatory and antifibrotic effects, prevented glomerulosclerosis and upregulated renal endothelial NO synthase in a rat model of salt-sensitive hypertension associated with increased angiotensin II-dependent activation of nicotinamide adenine dinucleotide phosphate oxidases [33].