The nomenclature of proteinopathies overlap with clinicopathological descriptions, like the grouping of FTLD as FTLD-tau, FTLD-TDP, FTLD-FUS, FTLD-UPS (when profiles immunoreactive only for the ubiquitin-proteasome system are detected) or FTLD-ni (when no specific inclusions are detected); or SCA for a group of trinucleotide repeat diseases. This evidence concerns the gene FUS and proteostasis deficiencies.