TDP-43 pathology frequently associates with other disorders, including AD, DLB, and frequently with a hippocampal sclerosis (HS; a disorder affecting about 10% of individuals over the age of 85 years [203]) of ageing (in around 90% of cases), but also chronic traumatic encephalopathy; some of these associate with genetic risk factors [19,203,204,205,206,207]. The gene discussed is TARDBP; the disease is Lewy body dementia.