Sporadic disorders of FTLD, such as basophilic inclusion body disease (BIBD), atypical FTLD-U (aFTLD-U), and neuronal intermediate filament inclusion disease (NIFID), feature neuronal (cytoplasmic/nuclear) and glial cytoplasmic inclusions immunoreactive for FUS, thus establishing a new category (FUS/FET proteinopathies) [21,41,218,219]. The gene discussed is FUS; the disease is proteostasis deficiencies.