A recent study suggested that TDP-43 deposition in AD follows a stereotypic progression in five distinct topographic stages, supported by correlations with neuroimaging and clinical features [211,212]: stage I involves the amygdala; stage II spreads into entorhinal cortex and subiculum; stage III shows involvement of the dentate gyrus and occipitotemporal cortex; stage IV shows further spread into inferior temporal cortex; and finally stage V involves the frontal cortex and basal ganglia. Here, TARDBP is linked to Alzheimer disease.