Despite the many forms of biochemical modifications of tau protein (Table 2) [31], current classification of tauopathies focus on the differentiation of 3R and 4R and mixed 3R + 4R types, together with the banding patterns of sarkosyl-insoluble tau, and for further subclassification the morphology and anatomical distribution of neuronal and glial (astro- and oligodendroglial) immunoreactivities are considered. The gene discussed is MAPT; the disease is tauopathy.