While the Amot family members can inhibit the proliferation of non-tumor kidney epithelial MDCK cells and human embryonic kidney (HEK) 293 cells by inhibiting YAP [17-18], other studies indicate that Amot can act as a co-activator of YAP to promote the growth of hepatocarcinoma cells and breast cancer [19, 21]. Here, AMOT is linked to neoplasm.