CCN2 and renal cell carcinoma: Interestingly, Amot was co-localized and interacted with YAP in growing renal epithelial and RCC cells and knockdown of Amot preferably reduced the levels of nuclear YAP and YAP-downstream CTGF and Cyr61 expression, but increased the levels of YAP phosphorylation in both renal epithelial and RCC cells.