PITX2 and Menkes disease: The Pitx2 levels did not show significant downregulation in PanIN lesions compared to paraneoplastic pancreatic tissues (p = 0.076), however, were sharply decreased in WD-PDAC tissues (p = 0.001) and MD or PD-PDAC tissues (p < 0.001) compared to paraneoplastic pancreatic tissues (Figure 1E).