First, we investigated radiogenomic association of overall PADUA score and mutation frequency of 9 SMGs (VHL, PBRM1, SETD2, KDM5C, PTEN, BAP1, mTOR and TP53) in ccRCC [18] and no significant association was found (Figure 2). This evidence concerns the gene BAP1 and nonpapillary renal cell carcinoma.