GATA1 interacts with a histone methyltransferase, SET (Su(var)3–9, Enhancer of zeste, Trithorax) domain containing 7 (SETD7, SET7/9, KMT7), whose role in cancer is largely unknown [25, 26], to increase VEGF transcription by binding the VEGF core promoter and facilitating the recruitment of RNA Pol II and formation of transcription preinitiation complex. The gene discussed is SETD7; the disease is cancer.