SETD7 and breast cancer: However, the conditioned medium from GATA1- or SET7-overexpreesing breast cancer cells with VEGFR2 knockdown had similar effect on angiogenesis to the conditioned medium from GATA1- or SET7-overexpreesing breast cancer cells (Supplementary Figure S10E), suggesting that VEGFR2 is not required for GATA1 or SET7 modulation of VEGF expression in breast cancer cells.