In contrast, we found that micewith myeloid-specific STAT3-deficiency but simultaneous systemic hyperactivationof STAT3 (gp130757F/F LysMcre/STAT3flox mice) wereprotected from acute and chronic DSS-induced colitis as indicated by the lack ofweight loss (acute (Fig. 5A) and chronic colitis (Fig. 6A) model), no shortening of the colon on day 44(chronic colitis model, Fig. 6B) and normal architectureof the colonic mucosa on day 9 (acute colitis model; Fig.5C,D). Here, STAT3 is linked to colitis.