However, these studiesconfirmed that DSS treatment of WT mice had only a minimal effect on the frequencyof CD11b+Gr1+ cells in colon16, 38, 39.Importantly, we show that the expansion of G-MDSCs in the colon (but not in spleenor MLN) of gp130757F/F mice was markedly increased during acuteDSS-induced colitis, and G-MDSCs of gp130757F/F mice had a higherARG1 activity than WT mice. This evidence concerns the gene ITGAM and colitis.