To explore whether STAT3 activation in myeloid cells accounts for resistance toacute DSS-induced colitis in gp130757F/F mice, we analyzed thesusceptibility to acute and chronic DSS-induced colitis in mice withmyeloid-specific STAT3-deficiency (LysMcre/STAT3flox mice andgp130757F/F LysMcre/STAT3flox mice) (Fig. 5). This evidence concerns the gene STAT3 and colitis.