In contrast, gp130 ‘knock-in’mutant mice (gp130757F/F) which are incapable of activating the RAS/ERKpathway and have hyperactivation of STAT3 in response to gp130 engagement, are protectedfrom chemically induced colitis using dextran sulphate sodium (DSS)23, 24, 25. Here, STAT3 is linked to colitis.