In agreement with the observed protection of gp130757F/F mice fromacute DSS-induced colitis we found that gene expression of the pro-inflammatorymediators IL-1β, IL-6, IL-11, IL-17, IL-27, IFNγ andiNOS are all significantly reduced in the colons of DSS-treatedgp130757F/F mice (day 9) compared with DSS-treated WTlittermates (Fig. 3A). Here, IL6 is linked to colitis.