In the present study we therefore analyzedthe immunoregulatory role of the transcription factor STAT3 in experimental mouse modelsof IBD using gp130757F/F mice with systemic hyperactivation of STAT3;mice with a myeloid-cell specific deficiency of STAT3(LysMcre/STAT3flox); and mice with systemic hyperactivation of STAT3 witha myeloid-cell specific deficiency of STAT3 (gp130757F/FLysMcre/STAT3flox). This evidence concerns the gene STAT3 and inflammatory bowel disease.