2010). Interestingly enough, we showed subtle modifications in PTP regulation that could take place during maturation and adaptive response to hyperglycemia and hyperinsulinemia. These results are in agreement with studies showing links between PTP opening control, CypD content, and insulin resistance (Taddeo et al. 2014; Tubbs et al. 2014) that should now be taken into consideration to develop new therapeutic targets. The gene discussed is PPIF; the disease is Insulin resistance.