KCTD8 and cancer: KCTD8, 12 and 16 are identified as components of the auxiliary GABAB receptor subunits24, but only KCTD12 generates a desensitizing GABAB receptor response8, 25 and suppresses the proliferation of GIST cells via interference with GABAB signaling26, which has been reported to play important roles in several human cancers, including CRC27, 28.