Transgelin localized partially in the nucleus of the CRC cells; it shares 85 % similarity to TAGLN3, which is believed to be a transcriptional regulator [28]; Bioinformatic analysis using the DP-bind Web server (http://lcg.rit.albany.edu/dp-bind) identified several segments of transgelin as having high DNA-binding potential (data not shown); studies also suggests that nuclear actin-binding proteins participate widely in the transcription processes (reviewed in [49]). The gene discussed is TAGLN; the disease is colorectal carcinoma.