Classical HGPS is caused by a de novo heterozygous mutation (1824C>T, p.G608G) in exon 11 of LMNA (De Sandre-Giovannoli et al. 2003; Eriksson et al. 2003), which activates a cryptic splice donor site, resulting in the production of a prelamin A mRNA that contains an internal deletion of 150 base pairs. This evidence concerns the gene LMNA and Hutchinson-Gilford progeria syndrome.