Therefore, Osorio et al. created a mouse knock-in strain that carries a HGPS mutation in the mouse Lmna gene (LmnaG609G; 1827C>T; Gly609Gly) and produces progerin due to abnormal splicing of the endogenous Lmna mRNA like in HGPS patients (Osorio et al. 2011). Here, LMNA is linked to Hutchinson-Gilford progeria syndrome.