In addition to the classical 1824C>T HGPS mutation, other heterozygous, homozygous or compound heterozygous mutations in LMNA have been reported, such as T10I, A57P, L59R, R133L, L140R, S143F, E145K, V169fsX176, D300N, E578V and R644C and c.412G>A (Kirschner et al. 2005; Csoka et al. 2004; Chen et al. 2003; Caux et al. 2003; Jacob et al. 2005; Mory et al. 2008; McPherson et al. 2009; Doh et al. 2009; Renard et al. 2009; Doubaj et al. 2012; Kane et al. 2013), all causing atypical progeroid syndromes (APS). This evidence concerns the gene LMNA and autoimmune polyendocrinopathy.