Studies have shown that the positive expression rate of ICAM-1 was related with lymph node metastasis and depth of tumor invasion, and the VCAM-1 expression positive gastric cancers were more invasive and were associated with more lymph node metastases than VCAM-1 expression negative ones [43–45]. This evidence concerns the gene ICAM1 and metastatic malignant neoplasm in the lymph nodes.