KRT8 and neoplasm: As shown in Table 5, the primary and first generation of the tumor showed positive staining for VCAM-1 and CK8/18, but the subsequent generations showed weak staining for these proteins: VCAM-1 staining was scored as moderately positive (++) in the primary, weak signal (+) in the first generation, and CK8/18 staining was scored as weak signal (+) in the first generation.